Coeliac disease may be asymptomatic in many people, meaning they experience no gastrointestinal symptoms at all.
What are the symptoms of Coeliac Disease?
- Diarrhoea &/or constipation
- Fatigue and weakness
- Bloating/fluid retention
- Foul stools (steatorrhoea)
- Anaemia (low Iron)
- Abdominal cramping and discomfort
- Increased flatulence
- Lowered immune resistance
- Weight loss (in some cases weight gain)
- Failure to thrive (in children) including poor weight gain or delayed growth/puberty
- Mental “fogginess”
- Lowered mood/depression
- Nausea and vomiting
- Vitamin and mineral deficiencies, especially Vitamin D, K, B12, folate, zinc and calcium
Less common symptoms
- Recurrent mouth ulcers
- Recurrent miscarriage and infertility
- Skin conditions such as dermatitis herpetiformis
- Bone, muscle and joint pains
- Hyposplenism (a small and underactive spleen)
- Osteopenia or osteoarthritis (as a result of intestinal malabsorption of Vitamin D and calcium)
Coeliac disease may be asymptomatic in many people, meaning they experience no gastrointestinal symptoms at all.
How is Coeliac Disease Diagnosed?
Coeliac Serology
There are several tests used to screen for coeliac disease. Generally the initial test performed is a coeliac serology, which is a blood test. This includes:
- Anti-tissue transglutaminase antibodies (tTG)
- Deamidated gliadin peptide (DGP) IgA and IgG tests. The DGP IgG test can detect individuals with coeliac disease who may be deficient in IgA antibody, rendering the tTG IgA test unreliable in those cases.
- Anti- endomysial antibodies (EMA).
Gastroscopy
If a coeliac serology shows a positive a gastroscopy is then requested to confirm the diagnosis. This is where approximately 5 biopsies are taken of the duodenum at varying locations.
*It is important to note that if a gluten free diet has been implemented prior to testing, a coeliac serology and duodenal biopsies may show a false negative. It is recommended to include gluten in the diet on a regular bases for at least 6 weeks prior to the above testing.
Genetic Testing
Genetically Coeliac Disease is characterised by a strong human leucocyte antigen (HLA) component. More than 90% of people affected by coeliac disease carry at least one of the genes that encode HLA DQ2 or HLA DQ8. The risk for coeliac disease is greater in those with the HLA DQ2 genes compared with the HLA DQ8 genes. The genetic test can be done as a blood test or a buccal (cheek) swab.
Not all people that carry the gene will develop coeliac disease; therefore the genetic test alone cannot specifically diagnosed coeliac disease. However, the genetic test is not dependent on gluten intake so can be used when people have already implemented a gluten free diet.
Wendy Richards specialises in the management of gluten sensitivity and celiac disease. Wendy is available in clinic on Tuesday 11am -7pm, Wednesday 11am - 6pm, Thursday 10am – 2pm and every second Saturday 10am – 2pm. For bookings and enquiries please call the clinic on 03 9894 0014, Book Online or send us your general enquiries.